More on Alzheimer's

Growing evidence suggests that lifestyle interventions such as walking may help lower cognitive decline in individuals with the apolipoprotein E-4 (APOE-4)who have a genetically higher risk of developing Alzheimer's Disease-and may even provide greater benefits than in noncarriers.

Preliminary findings from a new study show that while men and women APOE-4 carriers experienced steeper declines in cognition over a 10 year period, regular walking appeared to mitigate these effects by preserving global cognition and exercise function.

The results underscore the value of accessible physical activity programs for individuals genetically at risk for AD, study investigator Cindy Barha, PhD, Canada Research Chair in Neuroscience, Brain Health and Exercise, and assistant professor, Faculty of Kinesiology, University of Calgary, Alberta, Canada.

Medscape, August, 2025

***Another good reason for each and everyone of us to meet the goal of 150 minutes of exercise per week.